SECURE CLOUD ACCESS

LD-OXY

LD-Oxy is intended for use:

1- To analyze the pulse waveform (Photoelectrical plethysmography or PTG) provided by the oximeter. 

2-    To analyze the basic rhythms of the NN or RR intervals in heart rate. Both in the time domain and in the frequency domain. 

The PTG analyses the peripheral circulation and detection of the beat to beat heart rate.
PTG uses transmitted infrared and red light to measure oxygen saturation and relative blood volume in the fingertip. PTG waveform are reflective of blood movement in cutaneous vessels and can be used to identify synchronous depolarization of cardiovascular tissue. 

CARDIAC AUTONOMIC REFLEX TESTS USING LD-OXY

FEATURES

- Photoplethysmography (PTG) analysis to assess the peripheral circulation and endothelial function.
- HRV (Heart Rate Variability) analysis both in the time domain and frequency domain to assess early ANS dysfunction
- Ewing Tests analysis (Valsalva maneuver, deep breathing and K30/15 tests) to assess cardiovagal failure.


REVIEW OF LD-OXY

LD-Oxy plethysmography analysis presents advantages compared to other competitive analysis.

ADVANTAGES OF THE LD-OXY OXIMETER 

- Accuracy of the heart rate detection: Comparing our algorithm using the first derivative of the photoplethysmography to EKG, the coefficient of correlation r=0.99.


-Accuracy of the HRV analysis. According to the standard ANSI/AAMI EC57, our results  are in compliance  with the Input MIT-BIH database. 

- Research and development i.e. clinical studies.
The PTG spectral analysis using LD-Oxy has a pending patent, and it is related to the autonomic nervous system and artery function as shown in clinical studies, and it returns a high specificity and sensitivity to detect pre-diabetes, diabetes and vascular diseases.


PTG Spectral analysis markers were compared to:

         - Gold standard of Insulin resistance assessment - Hyperinsulinemic Euglycemic Clamp  (HEC)
 PTG-TP marker returns a sensitivity = 95.7%, specificity =84,4% and the area under the ROC curve (AUC) = 0.929 for identifying insulin resistance. 

        - Oral Glucose Tolerance Test (OGTT)

The correlations between the OGTT and photoplethysmography index (PTGi) were: r = -0.56 (p = 0.003) for glucose and r = -0.41 (p =0.04)for insulin

        - Coronary angiography

 PTGi returns a sensitivity of  86.1% and specificity of 87.1% and the area under the ROC curve ( AUC) = 0.926 for identifying endothelial function.