The Sudomotor testing clinical data suggest it may be the most sensitive means to detect peripheral small fiber neuropathy (Low, et al.,2006).
Sudomotor function is controlled by part of the sympathetic nervous system (post sympathetic cholinergic fiber) and it relates to skin microcirculation and small demyelinated nerve fibers (C-Fibers).
Microcirculatory disorders and Small fiber neuropathy could be the earliest stages of peripheral distal neuropathy in diabetic patients.
In addition, sudomotor dysfunction has been found in different diseases or as medication side effects such as cancer treatment, antihypertensive treatment (in particular beta and alpha blockers and calcium antagonists), metformin treatment, vitamin deficiency, Parkinson's disease, AIDS, amyotrophic lateral sclerosis, hypothyroidism, kidney and liver diseases, alcoholism, Alzheimer's disease and Guillain-Barre syndrome.
Traditional and recognized neurophysiologic measurements of sudomotor function include thermoregulatory sweat testing (TST), quantitative sudomotor axon reflex testing (QSART), silicone impressions and sympathetic skin response (SSR)
Sudomotor dysfunction is used to define a decreased sudomotor activity.
Impaired response of autonomic C-Fiber ( low level or absence or acetylcholine production) or of capillaries vasodilation ( low or absence of response to Nitric Oxide) lead to sudomotor dysfunction.
The autonomic C-fiber response (Sweat Peak) is measured at the positive electrode.
The vasodilation response (NO Peak) is measured at the negative electrode.
DISPOSABLE ELECTRODE ADVANTAGES :
- No disinfection and no maintenance.
- Increased reproducibility (no ageing of the electrodes).
- Prevent cross contamination
- Prevent biased measurement from the temperature
- Prevent biased measurement from the size of the feet
NOTES! SweatC has been calibrated with special gel on the disposable electrodes and those electrodes are only sold by LD Technology. In case of use of other electrodes, LD Technology cannot warranty the accuracy of the measurements.